GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs11212617 | 1 | rs573890 | chr11:108251363 | ATM | chr11:108093559-108239826:+ | 0.11 | 3.67 | 0.00027 | Response to metformin in type 2 diabetes (glycemic);Response to metformin |
| THCA | cis | rs2241437 | 1 | rs57398459 | chr2:86291326 | LOC90784 | chr2:86247339-86250991:- | -0.36 | -3.43 | 0.000645 | Response to methylphenidate treatment in attention-deficit/hyperactivity disorder (blood pressure) |
| THCA | cis | rs2241437 | 1 | rs57398459 | chr2:86291326 | POLR1A | chr2:86253453-86333278:- | -0.29 | -3.78 | 0.000176 | Response to methylphenidate treatment in attention-deficit/hyperactivity disorder (blood pressure) |
| THCA | cis | rs9902453 | 1 | rs57411618 | chr17:28273052 | ANKRD13B | chr17:27916801-27941778:+ | 0.37 | 9.19 | 1.19E-18 | Coffee consumption (cups per day) |
| THCA | cis | rs9902453 | 1 | rs57411618 | chr17:28273052 | CORO6 | chr17:27941774-27948441:- | 0.51 | 12.08 | 1.59E-29 | Coffee consumption (cups per day) |
| THCA | cis | rs9902453 | 1 | rs57411618 | chr17:28273052 | EFCAB5 | chr17:28256874-28435469:+ | 0.59 | 11.28 | 2.54E-26 | Coffee consumption (cups per day) |
| THCA | cis | rs9902453 | 1 | rs57411618 | chr17:28273052 | GIT1 | chr17:27900487-27916610:- | 0.3 | 6.98 | 9.68E-12 | Coffee consumption (cups per day) |
| THCA | cis | rs9902453 | 1 | rs57411618 | chr17:28273052 | LRRC37B2 | chr17:28903483-28992715:+ | 0.18 | 3.93 | 9.65E-5 | Coffee consumption (cups per day) |
| THCA | cis | rs9902453 | 1 | rs57411618 | chr17:28273052 | SSH2 | chr17:27952965-28257018:- | 0.33 | 7.59 | 1.64E-13 | Coffee consumption (cups per day) |
| THCA | cis | rs9902453 | 1 | rs57411618 | chr17:28273052 | TP53I13 | chr17:27895739-27900174:+ | 0.2 | 5.46 | 7.66E-8 | Coffee consumption (cups per day) |
| THCA | cis | rs9546434 | 1 | rs57415683 | chr13:36684221 | SOHLH2 | chr13:36742347-36871992:- | 0.32 | 4.34 | 1.72E-5 | Optic cup area |
| THCA | cis | rs5743030 | 1 | rs5743030 | chr2:190678545 | ASNSD1 | chr2:190526125-190535556:+ | -0.69 | -7.33 | 9.94E-13 | Subcutaneous adipose tissue |
| THCA | cis | rs5743030 | 1 | rs5743030 | chr2:190678545 | ORMDL1 | chr2:190634994-190649097:- | 0.23 | 3.42 | 0.000686 | Subcutaneous adipose tissue |
| THCA | cis | rs5743030 | 1 | rs5743044 | chr2:190683265 | ASNSD1 | chr2:190526125-190535556:+ | -0.68 | -6.62 | 9.54E-11 | Subcutaneous adipose tissue |
| THCA | cis | rs5743030 | 1 | rs5743112 | chr2:190708982 | ASNSD1 | chr2:190526125-190535556:+ | -0.57 | -5.94 | 5.52E-9 | Subcutaneous adipose tissue |